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What Causes Scleroderma?

The cause of scleroderma is unknown. What we do know is that people with scleroderma have activation of their immune system. In addition they are producing too much collagen and thirdly some of their small blood vessels become narrowed. It is the combination of these three events that produces the various clinical features of scleroderma. One suggestion about what causes scleroderma is that something in their body damages some of the small blood vessels. This in turn activates the immune system and the activated immune system makes chemicals that switch on the fibroblasts. These activated fibroblasts then produce excessive collagen.